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Immunology & Immunological Disorders Poster Session






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
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Induction of Th1-type cytokines in vitro by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal preparation.


Contact Person: Masato Okamoto (mokamoto@dent.tokushima-u.ac.jp)


References

  1. Okamoto H, Shoin S, Koshimura S, Shimizu R (1967) Studies on the anticancer and streptolysin S-forming abilities of hemolytic streptococci. Jpn J Microbiol., 11:323-36.
  2. Ono T, Kurata S, Wakabayashi K, Sugawara Y, Saito M, Ogawa H (1973) Inhibitory effect of a streptococcal preparation (OK-432) on the nucleic acid synthesis in tumor cells in vitro. Jpn J Cancer Res., 64:59-69.
  3. Sakurai Y, Tsukagoshi S, Satoh H, Akiba T, Suzuki S, Takagaki Y (1972) Tumor-inhibitory effect of a streptococcal preparation (NSC-B116209). Cancer Chemother Rep., 56:9-17.
  4. Okamoto H, Shoin S, Koshimura S (1978) Streptolysin S-forming and anticancer activities of group A streptococci. In: Jeljaszewicz J, Wadstrom T, eds. Bacterial toxin and cell membranes. New York: Academic Press, 259-89.
  5. Kimura I, Ohnishi Y, Yasuhara S, Watanabe T, Sugiyama M, Kiraki K (1974) Studies on the host-mediated action of the streptococcal preparation, OK-432, in cancer chemotherapy. Acta Med Okayama, 28:423-31.
  6. Ishii Y, Yamaoka H, Toh K, Kikuchi K (1976) Inhibition of tumor growth in vivo and in vitro by macrophages from rats treated with a streptococcal preparation, OK-432. Jpn J Cancer Res., 67:115-9.
  7. Oshimi K, Kano S, Takaku F, Okumura K (1980) Augmentation of mouse natural killer cell activity by a streptococcal preparation, OK-432. J Natl Cancer Inst., 65:1265-9.
  8. Oshimi K, Wakasugi H, Seki H, Kano S (1980) Streptococcal preparation, OK-432 augments cytotoxic activity against an erythroleukemic cell line in humans. Cancer Immunol Immunother., 9:187-92.
  9. Matsubara S, Suzuki F, Ishida N (1979) Induction of immune interferon in mice treated with a bacterial immunopotentiator, OK-432. Cancer Immunol Immunother., 6:41-5.
  10. Ebina T, Sakai A, Saito M (1981) Interferon induction and augmentation of natural killer cell activity by immunopotentiators (in Japanese). Igakunoayumi, 117:229-34.
  11. Sato M, Yoshida H, Yanagawa T (1984) Effects of intradermal administration of streptococcal preparation OK-432 on interferon and natural killer cell activities in patients with oral cancer. Int J Oral Surg., 13:7-15.
  12. Hoshino T, Iho S, Kura F, Uchida A (1986) In vivo and in vitro biological effects of OK-432, a streptococcal preparation, on the augmentation of autologous tumor cell killing activity and cytokine production of lymphocytes and monocytes in malignant deseases. In: Micksche M, Klein E, eds. OK-432. A biological response modifier. Tokyo: Professional Postgraduate Services, International, 61-8.
  13. Nagamuta M, Yamamoto A, Usami Y (1986) Induction of TNF in peritoneal fluid of mice treated with OK-432. In: Ishida N, ed. Mechanisms of antitumor effects of OK-432. Tokyo: Excerpta Medica, 126-36.
  14. Djeu JY, Heinbaugh JA, Holden HT, Herberman RB (1979) Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J Immunol., 122:175-81.
  15. Herberman RB, Ortaldo JR, Mantovani A, Hobbs DS, Kung HF, Pestka S (1982) Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol., 67:160-7.
  16. Peri G, Polentaruti N, Sessa C, Mangioni C, Mantovani A (1981) Tumoricidal activity of macrophages isolated from human ascitic and solid ovarian carcinomas: augmentation by interferon, lymphokine and endotoxin. Int J Cancer, 28:143-52.
  17. Yanagawa E, Toge T, Niimoto M, Hattori T (1986) In vitro augmentation of natural and autotumor killing activity of tumor-associated macrophages by OK-432, interleukin-2, and interferon. In: Hoshino T, ed. Immunopharmacological aspects of OK-432 in humans. Tokyo: Excerpta Medica,17-26.
  18. Gidlund M, Orn A, Wigzell H, Senik A, Gresser I (1978) Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature (Lond), 273:759-61.
  19. Schultz RM, Papamatheakis ID, Chirigos MA (1978) Functional and morphologic characteristics of interferon-treated macrophages. Cell Immunol.,35:84-91.
  20. Okamoto M, Kaji R, Kasetani H, Yoshida H, Moriya Y, Saito M, Sato M (1993) Purification and characterization of interferon-g-inducing molecule of OK-432, a penicillin-killed streptococcal preparation, by monoclonal antibody neutralizing interferon-g-inducing activity of OK-432. J Immunother., 13:232-42.

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<= Discussion & Conclussions REFERENCES

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Okamoto, M.; Goda, H.; Ohe, G.; Yoshida, H.; Sato, M.; (1998). Induction of Th1-type cytokines in vitro by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal preparation.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/immunology/okamoto0234/index.html
© 1998 Author(s) Hold Copyright