Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
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Fig.1: d-Fenfluramine induces a carrier-dependent release of unmetabolized [³H]5-HT, both in absence and presence of pargyline. This experiment was carried out in a calcium-free medium to exclude the calcium-dependent component of dF-induced release (suggested to be exocytotic-like and not carrier-mediated, Gobbi et al., 1993; Crespi et al, 1997).

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Fig.2: RO4-1284 induces a dose-dependent tritium release from [³H]5-HT preloaded synaptosomes

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Fig.3: Although quite rapid, the release induced by RO4-1284 is delayed as compared with the dF-induced release

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Fig.4: In the presence of pargyline, the release induced by RO4-1284 is mainly due to unmetabolized [³H]5-HT, while in the absence of pargyline it was mainly due to [³H]5-HIAA.

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Fig.5: However, either in the presence or absence of pargyline, the RO4-1284 induced release is calcium- and carrier-independent

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