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Invited Symposium: Behaviour-Induced Neural Events after Brain Injury






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
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The Effects Of Behavioral Demand On Motor Cortical And Cerebellar Structural Plasticity After Brain Injury In Adult Rats


Contact Person: Scott D. Bury (sbury@u.washington.edu)


References

  1. Black, J.E., Isaacs, K., Anderson, B.J., Alcantara, A.A., and Greenough, W.T. (1990) Learning causes synaptogenesis whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proceedings of the National Academy of Sciences USA, 87: 5568-5572.
  2. Boyeson, M.G., Krobert, K.A. (1992) Cerebellar norepinephrine infusions facilitate recovery after sensorimotor cortex injury. Brain Res. Bull., 29: 435-439.
  3. Boyeson, M.G., Krobert, K.A., Scherer, P.J. and Grade, C.M. (1993) Reinstatement of motor deficits in recovered brain injured animals. Restor. Neurol. Neurosci., 5: 283-290.
  4. Chu, C.J., Grande, L.A., Gregory, A., Kim J.H., and Jones, T.A. (1997) Motor skills training effects on cortical structural plasticity and behavioral function following unilateral sensorimotor cortex damage in adult rats. Society for Neuroscience Abstracts 23: 231.
  5. Greenough, W.T. (1990) Learning causes synaptogenesis whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proceedings of the National Academy of Sciences USA, 87: 5568-5572.
  6. Jones, T.A., Schallert, T. (1992) Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res. 581: 156-160.
  7. Jones, T.A., Kozlowski, D.A. and Schallert, T. (1993) Growth of pyramidal neurons contralateral to unilateral sensorimotor cortex lesions: Behavior and degenerative effects. Society for Neuroscience Abstracts, 19: 163.
  8. Jones, T.A. and Schallert, T. (1994) Use-dependent growth of pyramidal neurons after neocortical damage. J. Neurosci., 14: 2140-2152.
  9. Jones, T.A., Kleim, J.A. and Greenough, W.T. (1996) Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination. Brain Research, 733: 142-148.
  10. Jones, T.A. (1997) Evidence for alterations in the form of synaptic connectivity in the cortex opposite unilateral sensorimotor cortex lesions: time-dependent degenerative and synaptic structural changes. Society for Neuroscience Abstracts, 22: 1395.
  11. Kleim, J.A., Swain, R.A., Armstrong, K.A., Napper, R.M., Jones, T.A., Greenough, W.T. (1998) Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning. Neurobiology of Learning and Memory, 69: 274-89.
  12. Klintsova, A.Y., Matthews, J.T., Goodlett, C.R., Napper, R.M., Greenough, W.T. (1997) Therapeutic motor training increasses parallel fiber synapse number per Purkinje neuron in cerebellar cortex of rats given postnatal binge alcohol exposure: preliminary report. Alcoholism, Clinical and Experimental Research, 21: 1257-63.
  13. Klintsova, A.Y., Cowell, R.M., Swain, R.A., Napper, R.M., Goodlett, C.R., Greenough, W.T. (1998) Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats. Brain Research, 800: 48-61.
  14. Kozlowski, D.A., James, D.C., Schallert, T. (1996) Use Dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. Journal of Neuroscience, 16: 4776-86.
  15. Uylings, H.B.M., Kuypers, K., Diamond, M.C. and Veltman, W.A.M. (1978) Effects of differential environments on plasticity of dendrites of cortical pyramidal neurons in adult rats. Exp. Neurol., 62: 658-677.

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<= Discussion & Conclussions REFERENCES

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Bury, S; Grande, L; Ishida, J; Zitzka, A; Jones, T; (1998). The Effects Of Behavioral Demand On Motor Cortical And Cerebellar Structural Plasticity After Brain Injury In Adult Rats. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/schallert/bury0827/index.html
© 1998 Author(s) Hold Copyright