Invited Symposium: What Can Genetic Models Tell Us About Attention-Deficit Hyperactivity Disorder (ADHD)?
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Sadile, A.G. (Lab. Neurophysiol. Behav. & Neural Networks, II Univ. Naples, Naples, Italy.)
Abstract
Genetic models are important for research on the neural networks of attention as well as on ADHD. We used Naples-High Excitability (NHE) rats and Naples Low-Excitability (NLE) rats with random-bred (NRB) rats as controls. NHE/NLE rats were crossings and rearings in spatial novelty tasks. Quantitative cytochrome oxidase (C.O.) histochemistry served to measure long-lasting changes in tissue metabolic capacity. C.O. was measured in 65 regions, including all major brain systems. Differences between the NLE and NHE were found in the granular cell layer of the outer blade of the dentate gyrus. NLE showed greater C.O. activity than NRB in medial frontal cortex, and lower activity in perirhinal cortex (dorsal region). NHE showed greater C.O. activity than NRB in entorhinal cortex (superficial layers) and lower activities in perirhinal cortex and cortical amygdala. These data support the hypothesis that NLE/NHE rats may be an appropriate model for studying genetically altered limbic regions related to impaired emotional processing. They support the involvement of limbic circuits in attentive processes and impulsiveness, and the use of the NLE/NHE strains as animal models of ADHD in children. (Supported by grants NSF-IBN9222075, NIH-NS37755 and EC grant FRBCHRXCT930303).
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Presentation Number SAgonzalez-lima0394
Keywords: cytochrome oxidas, histochemistry, hyperactivity, attention, limbic system
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