Invited Symposium: Arachidonic Acid Metabolites, Other Inflammatory Mediators and Intestinal Ion Transport
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Skadhauge, Erik (Dept. of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Denmark)
Rangachari, Patangi K. (Dept. of Medicine, McMaster University, Canada)
Abstract
The isoprostanes are novel prostaglandin (PG)-like compounds formed in vivo by the free-radical catalyzed peroxidation of arachidonic acid, synthesized independent of the cyclooxygenase, and their side-chains have cis orientation. Their biological effects have been documented on several test systems though information on their gastrointestinal effects are sparse. Earlier work suggested that the isoprostanes had effects both on the canine colonic epithelium and the muscularis mucosae. The pig jejunum also responded to one of the isoprostanes (8-iso-PGE2). We will discuss the potential implications of physiological, pathophysiological and pharmacological implications of such studies. M.A.Unmack gratefully acknowledges the support of The Else and Mogens Wedell-Wedellsborg Foundation, The King Christian IX and Queen Louise Anniversary Foundation, The Dagmar Marshall Foundation, The Ingeborg Roikjer Foundation, Landed Proprietor Viktor A. Goldschmidt Foundation (Dept. B), The Novo Nordisk Foundation, and The Carlsberg Foundation (RVAU). P.K.Rangachari was supported by MRC Canada.
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Presentation Number SAunmack0591
Keywords: Prostaglandins, Ion Transport, Secretion, Desensitization, Jejunum
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