Abstract

Introduction

Collateral Development and Hypertension

Collateral Development and Aging

CONCLUSION

Reference List

Discussion
Board

Shear-mediated vascular remodeling has been demonstrated to be of primary importance in collateral development. An intact endothelium has been shown to be essential in this phenomenon. Consequently, shear-mediated collateral development could be altered in animals with endothelial dysfunction. We utilized spontaneously hypertensive and mature rats to determine if vascular remodeling was altered in small resistance arteries, which formed collateral pathways, and were exposed to chronic elevation of shear. In young-normotensive rats, luminal expansion, intimal hyperplasia and medial hypertrophy were observed one week following abrupt elevation of shear stress. However, in mature animals intimal hyperplasia and medial hypertrophy occurred without luminal expansion. In hypertensive animals, intimal hyperplasia was observed in the collaterals without medial hypertrophy or luminal expansion. The results indicate that shear-mediated regulation of structural arterial diameter is suppressed and the associated wall remodeling altered in two different animal models characterized with endothelial dysfunction. Supported by NIH HL 42898.

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Presentation Number SAtuttle0776
Keywords: shear stress, aging, hypertension, remodeling, collateral