Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
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Vanadate mediates a tyrosine kinase dependent enhancement of adenylyl cyclase isoform VI activity; further, this is related to a tyrosine kinase-dependent serine phosphorylation of the catalytic subunit. Mutation of serine residues located in and adjacent to the C_1b catalytic region completely abrogates the vanadate-mediated enhancement of adenylyl cyclase activity. Tyrosine kinase-dependent serine phosphorylation represents a novel mechanism whereby tyrosine kinase activation may modify G-protein linked responses.

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