Pharmacology & Toxicology Poster Session |
Results
Table 1 summarizes 6 radioisotopes, their half-lives, their principal gamma-ray energy, and their estimated chemical species used in this work.
Table. 1. Used radioisotopes, their half-lives, their principal gamma-ray energy, and their estimated chemical species. Radioisotope Half-life (d) Principal gamma E(keV), Chemical species ------------------------------------------------------------------- 46Sc 83.8 889 1121 Sc3+ 54Mn 312.2 835 Mn2+ 65Zn 244 1116 Zn2+ 75Se 119.8 265 401 SeO32+ 83Rb 86.2 530 553 Rb++ 88Zr 83.4 394 ZrO2+ ZrO2 ---------------------------------------------------------------------In this work, the multitracer solution enables simultaneous tracing of 6 trace elements (Rb, Zn, Se, Mn, Sc and Zr) in the identical regions and a strict comparison of their biobehavior. At 48 h after i.p. injection, the regional uptake rates of Rb, Zn, Se, Mn, Sc and Zr tracers are shown in Fig.2 . The uptake rate of Rb, Zn and Se in aged mice were found to be higher than those of young mice, and not large difference among all regions. However, the uptake rates of Mn, Sc and Zr tracers in aged mice have fairly large difference and substantially higher values.
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Fig. 2. Aging effect on the regional uptake rates in the brain of normal mice.
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Amano, R.; Oishi, S.; Enomoto, S.; (1998). Regional uptake behaviors of radioactive Rb, Zn, Se, Mn, Sc and Zr tracers in brain of young and aged C57BL/6N mice. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/pharmtox/amano0433/index.html | |||||||||||
© 1998 Author(s) Hold Copyright |