Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
Board

The effect of endogenous histamine on spatial cognition was investigated with 8-arm radial maze in rats. Intracerebroventricular (i.c.v.) injection of Éø-fluorome thylhistidine (Éø-FMH), a selective inhibitor of histidine decar- boxylase, resulted in spatial memory deficits, which are characterized by an increase in the number of total error (TE) and a decrease in the number of initial correct response (ICR). There is a high correlation between an increase in the number of TE and a decrease in histamine contents of the cortex and hippo- campus, which are known to partici pate in learning and memory. On the other hand, both histamine (50-100 ng, i.c.v.) and thioperamide (10*É mg(microgrammer), i.c.v.) signi- ficantly ameliorated on memory deficit induced by Éø-FMH. However, metoprine showed no significant effect on Éø FMH-induced memory deficit. Pyrilamine and R-(Éø)-methylhistamine enhanced the memory deficit induced by Éø-FMH, at doses which caused no appreciable effect when they were given alone. In contrast, no significant influence was observed with zolantidine in Éø-FMH-induced memory deficit.

Back to the top.
Poster Number PAchen0322
Keywords: Histamine, Éø-FMH, Radial maze, Thioperamide, Pyrilamine