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No difference in age, gender, height, weight, serum cholesterol or triglycerides among the two groups was observed (data not shown). As expected, clinic blood pressure, plasma renin activity and plasma aldosterone were greater in RVH and PA than in NT (Table 1).
TABLE 1 Haemodynamic and humoral data
NH EH PA RVH
BP (mm Hg) 127/79±8/7 162/99±8/7 170/103±13/9 *** 163/104±16/12 ***
PRA (ng/ml/h) 1.1±1.2 1.2±1.1 0.20±0.31 6.23±6.17 *#
ALDO(pmol/ml) 0.30±0.28 0.41±0.30 1.53±0.60 ***# 1.22±0.72 **#
*=P<0.05, *** = P < 0.001 compared with NT, #=p<0.05 at least compared with EH. BP=blood pressure, ALDO= plasma aldosterone.
The morphological data in the different groups are summarized in Table 2.
TABLE 2 Morphological characteristics of the subcutaneous small resistance vessels. NT EH PA RVH Normalized ID(mm) 306±83 245±68 * 230±71 * 227±73 * M/L (%) 5.8±1.5 8.6±2.0 *** 9.9±3.1 *** 12.0±5.0 ***# MCSA (mm2) 14011±5302 16002±7991 17540±7218 21914±9433 * CV (mm-3 *10-3) 2.05±0.32 2.28±0.44 2.42±0.64 3.03±0.83 ***# Cell length (mm) 72±11 77±20 84±21 87±22 NCSL (mm-1) 9.0±3.7 6.1±2.9 9.3±3.7 9.1±4.5 CL 4.5±1.1 4.1±1.4 5.3±1.4 4.7±1.4*=P<0.05; ** = P < 0.01; *** = P < 0.001 compared with NT, #=p<0.05 at least compared with EH.ID= internal diameter, M/L=media to lumen ratio, MCSA=media cross-sectional area, CV=cell volume, NCSL=number of cells per segment length, CL=cell layers. Back to the top.
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