Abstract

Introduction

1. Cell calcium metabolism and ischemia

2. Mitochondria and ischemic cell death

References

Discussion
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Ischemia is accompanied by mitochondrial dysfunction leading to fall in ATP concentration and phosphorylation potential, and loss of cellular ion homeostasis. Particularly, the raise in intracellular calcium concentration due to bioenergetical failure is believed to be harmful for cells. Following brief ischemic insults, mitochondrial function is usually normalized in the early reperfusion period and the ion concentration gradients are re-instituted. However reperfusion, especially following long-lasting ischemic periods, may be accompanied by secondary mitochondrial failure, which can trigger a lethal cascade of events known as apoptosis, or cause necrotic cell death. Recently there is accumulating evidence revieling the possible scenario of pathophysiological and biochemical mechanisms which orchestrate the events playing a significant role in ischemic cell death.

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Presentation Number SAkristian0829
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