Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
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INTRODUCTION:The existence of a tissular injury and/or acute inflammation it's characterized by high alterations in a serum values of a certain number of a hepatic derived proteins: APR or APP ( Acute Phase Reactants or Acute Phase Proteins ). Alpha 1 antitrypsin ( A1AT ) is a highly polymorphic protein in the group of Alpha 1 Globulins with an electrophoretic motility of 5'42 and a molecular weigh of 45000. OBJETIVE: The aim of this study was to evaluate of the usefulness of the determination of A1AT in Orthopedics Postoperative Period ( First 6 days in comparison with Preoperative Control ). PATIENTS AND METHODS: Serum samples were obtained from 22 patients with Pathology that required Orthopedics Surgery of both sexes and of 19 to 77 years of age, with non-infective and non-immunologic pathology, and untreated at the moment of the study. The A1AT values were obtained by quantitative determination in the ARRAY system of Proteins by rate Nephelometry. The Statistics analysis of the results it's processed by BMDP ( 1D, 7D ). RESULTS AND CONCLUSIONS: The values of A1AT in the 6 First Postoperative days it's correlated with the Body Temperature, and it's high in the patients with fever ( 368'944+/-23'684 mg% ) to compare with patients without fever ( 286'151+/-54'833 mg% ) and their differences were highly significant p less than 0'0001 ( p < 0'0001).

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Poster Number PArodriguez moreno0653
Keywords: ACUTE PHASE, PROTEINS, ORTHOPEDICS, SURGERY, POSTOPERATIVE