Abstract

Introduction

Materials and Methods

Results

Summary

References

Discussion
Board

Much attention has focused on the role that oxidative damage plays in cellular and organismal aging. The C. elegans gene mev-1 confers resistance to oxidative stress and modulates longevity. We have cloned mev-1 by transformation rescue and found that it encodes cyt-1 encoding the large subunit of succinate dehydrogenase cytochrome b. A missense mutation abolishes complex II activity in the mitochondrial membrane. These data indicate that CYT-1 participates to mediate electron transfer. Moreover, mutational inactivation of this process renders animals susceptible to oxidative stress and as a result, leads to precocious aging.

Back to the top.
Presentation Number SAishii0263
Keywords: ageing, oxidative stress, C. elegans, mev-1, cytochrome b