Invited Symposium: Molecular Mechanisms of Ageing
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Abstract
Over viewOver viewo We can easily distinguish an old person from a young person. However, the aging process varies greatly with the individual. Our maximum lifespan is limited and nobody has ever lived over 150 years. Thus aging is a variable but tightly programmed biological phenomenon. We know very little why and how we age. Elucidation of the mechanism of aging and deceleration of aging is one of the final frontiers of biomedical science. Although recent advances in molecular biology are giving us many epoch-making findings to solve the exciting mystery, 'Molecular Mechanism of Aging,' we are far from the establishment of a general concept, which explains the aging process. Now we need to collect, accumulate and analyze as much information as possible by the researchers in various areas of science. Thus, I organized this symposium 'Molecular Mechanism of Aging,' and selected ten invited speakers who are studying aging using various methods and animal species. Dr. Takagi is trying to create a new concept of cellular lifespan using Paramedium. Dr. Ishii has used nematode to analyze the etiology of oxidative damage in aging. Dr. Hosokawa is analyzing aging and age-associated disorders using a mouse model of accelerated senescence. Dr. Noda has been using molecular biological techniques to elucidate the mechanism of senescence growth arrest in human cultured cells. Dr. Toda is using a proteome technique to analyze age-associated changes in protein expression. Dr. Goto has biochemically studied the modificationof proteins during aging. Dr. Chung is investigating energetically the repair system of oxidized DNA. Dr. Naiki has been investigating the mechanism of Ab amyloid fibril formation using an in vitro system. Dr. Shimada has studied morphologically the cultured Purukinje cell. Finally, Dr. Johnson a leading opinion reader of the aging science, will summarize the important roles of stress response in aging and longevity.
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Presentation Number SAhiguchi0474
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