Arachidonic Acid Metabolites, Other Inflammatory Mediators and Intestinal Ion Transport

Re: Reply to MacNaughton

On Mon Dec 14, P.K.Rangachari wrote
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You had asked a question about receptors for EETs and the efects of COX inhibitors. In some instances, the effects of EETS are inhbited by indomethacin , in others not. Re: Receptors, little is known. There is apaper by Wong et al (1993) where they show high affinity binding sites for 14(R) 15(S)-EET on a membrane prep from guinea-pig mononuclear cells. Antagonists for TP, LT and PAF receptors did not displace binding (J.Lipid Mediators 6:199-208).

Thanks, Chari. Here's another one for you. Do EETS or other non-PG metabolites of arachidonic acid affect the levels of expression of COX (either COX-1 or COX-2)?

Tue Dec 15