Pharmacology & Toxicology Poster Session

Re: Poster 775

Dear Dr Grover,

Thanks for the comment and yes I am enjoying the meeting. You are right, the northern blot data would suggest that GRK-2 mRNA is not the answer for the increase in GRK-2 protein expression. Altered protein stability in a strong possibility as a potential explanation for the increase in GRK-2 protein expression in both human and rat lymphocytes and rat vascular tissues.

Thanks for your comments,

Rob Gros

On Sun Dec 6, Grover wrote
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>"Dr. Gros: I am glad to see your nice presentation and hope you enjoy the meeting. You conclude that the increased GRK-2 protein content in hypertension is not due to an increase in GRK-2 messenger RNA. Do you think then the mechanism involves a difference in protein stability or translation?"
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Mon Dec 14