Novel Cellular and Molecular Mechanisms in Allergic Inflammation

Starting comments on the presentation by Wardlaw

Dear Andy,

Clearly L-selectin has a wide range of receptors, including CD34. Is there any reason to believe that eosinophil development in/release from the bone marrow from CD34+ cells or/and in marrow stromal endothelium will be affected by targetting L-selectin/CD34 pathways? The one paper in Blood on CD34-/- mice showed defective eosinophil responses to allergen, but otherwise no hemopoietic defect.

Judah Denburg

Sat Dec 5