Carbon Monoxide and Cardiovascular Function

Re: symposium 200

On Fri Dec 4, grover wrote
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>Dr. Wang: Great presentation. Hope you have fun at the meeting.A couple of questions. First, by what mechanism would CO change Kca channels? Is it a direct action on the channel or does it involve intermediat metabolites? Which tissues show a change in the HO expression in diabetes? Is it only vascular smooth muscle or is it a broader phenomenon?
>

Thanks.

(1) CO can induce an chemical modification of histidine residue of KCa channels, changing their open probabiliy. See our paper on J.B.C. 272: 8222, 1997.

(2) Increased HO-1 expression in diabetes has been shown in STZ-induced diabetic rats (Diabetes 47:1318, 1998). Diminished HO-1 expression was found in diabetic in retinal pigment epithelium cells (Curr Eye Res. 16: 380,1997). It looks like that HO-1 change in diabetes is a general phenomenon but has tissue-specific patterns.

Sat Dec 5