Abstract

CLINICAL HISTORY

MATERIAL AND METHODS

PATHOLOGIC FINDINGS

DISCUSSION

REFERENCES

Discussion
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Background Preservation of antigenicity in cells showing the histological features of coagulative necrosis has been reported. Immunohistochemistry can provide a valuable complementary information to conventional histology in the evaluation of the infarcted lymph nodes, and may be applied to necrotic tissue in general. In such situations immunoperoxidase studies may yet be of value in establishing the basic histogenesis of the process. They may provide insight into the underlying lymphoid architecture and the cell size of any neoplastic proliferation. Clinical history We report a patient with a large splenic mass barely modified on its size after several lines of therapy and that was totally constituted for no viable tissue (massive coagulative necrosis). The most necrotic cells had a strong surface membrane reactivity with CD45 (LCA), CD79 alfa and CD20 (L26). CD3, CD43 (MT1), CD45RO ank keratins were negative. No background staining was present. Conclusions The singularity of this case resides in the persistence of post-treatment residual mass does not necessarily portend the existence of viable lymphoma and in the possibility to assure the tumoral origin of coagulative necrotic tissue by immunophenotypic studies. The histological diagnosis makes us consider the patient in remission.

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Poster Number PAvega0181
Keywords: Necrosis, residual mass, Immunophenotypic, lymphoma