Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
Board

Aminopeptidases (AP), have been involved in the metabolism of several physiologically relevant circulant and local peptides. To evaluate the local role of AP in BC, we measured alanyl- (AlaAP), arginyl- (ArgAP), cystinyl- (CysAP), glutamyl- (GluAP), aspartyl- (AspAP) and pyroglutamyl- (pGluAP) aminopeptidase activities, in their soluble and membrane-bound forms, in BC tissue after surgery, from which we separated samples of neoplastic tissue, adjacent tumoral tissue and non affected surrounding tissue. Comparing with non affected tissue, the results demonstrated highly significant modifications of speific soluble and membrane-bound AP activities, esentially in neoplastic tissue. Samples of neoplastic tissue demonstrated a significant increase of soluble AlaAP, ArgAP and CysAP, as well as membrane-bound ArgAP. However, membrane-bound AspAP and pGluAP activities decreased significantly, respectively in neoplastic tissue and in neoplastic and adjacent tissues. These results may reflect the functional status of their substrates, which could be selectively activated or inhibited locally in the affected tissue, due to the specific conditions that implies the tumoral process.

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Poster Number PAmartinez0389
Keywords: aminopeptidases, breast cancer, Human tissue