INABIS '98 - High rate of induction of human autologous cytotoxic T lymphocytes against renal caricinoma cells cultured with an interleukin cocktail

High rate of induction of human autologous cytotoxic T lymphocytes against renal caricinoma cells cultured with an interleukin cocktail
Liu, SQ (Deparment of Biomedical Engineering, Johns Hopkins University, USA)

Contact Person: Shu Q Liu (sliu@bme.jhu.edu)

Abstract

A high rate of induction (9/10) of human autologous cytotoxic T lymphocytes (CTL) was achieved in vitro from peripheral blood mononuclear cells of renal carcinoma patients by applying an interleukin (IL) cocktail consisting of IL-1,-2,-4, and 6 The CTL specifically lysed their own target carcinoma cells within 24 h but did not kill neighbouring autologou normal kidney cells or allogeneic renal cancer cell lines. In the case of TUHR4TKB, in which case autologous CTL were not induced, no expression of MHC class-I molecules was observed on the surface of these carcinoma cells, although they were sevsitive to autologous natural killer cells. The results imply that adoptive immunotherapy for metastasized renal carcinoma will be feasible with autologous CTL in combination with natural killer cells.

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Poster Number PAliu0167
Keywords: CTL, renal carcinoma, induction, immunotherapy, interleukin

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Liu, SQ; (1998). High rate of induction of human autologous cytotoxic T lymphocytes against renal caricinoma cells cultured with an interleukin cocktail. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/cancer/liu0167/index.html