Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
Board

Neuroblastoma is the most heterogenous childhood cancer in terms of clinical behaviour. The aim of this prospective study is to verify the prognostic significance of DNA ploidy, N-myc amplification and 1p36 deletion in neuroblastoma. We investigated 38 tumors from 24 patients with confirmed neuroblastoma. DNA diploid neuroblastomas often had amplified N-myc, del 1p36, clinical stage III or IV, and worse prognostic course. All but one tumors with N-myc amplification had also del 1p36. During chemotherapy induced maturation pre-chemotherapy DNA diploid tumors changed into an aneuploid. Our results confirm that patients with DNA aneuploid tumors had a better prognostic course and that children with neuroblastomas with more than 10 copies of N-myc and delp36 have a worse course. Determination of those markers enable us to divide patients into three prognostic groups.

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Poster Number PAeckschlager0530
Keywords: neuroblastoma, dna ploidy, n-myc amplif, del 1p36, prognosis