Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
Board

The role of histamine on compound 48/80-induced skin reactions was studied in mice. Subcutaneous injection of compound 48/80 into the rostral back of the mouse elicited dose-dependently the scratching behavior and skin vasal permeability of the injected site. Moreover, chronic treatment of compound 48/80 resulted in a significant decrease in the scratching behavior and histamine contents of the injected site. Classical histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine caused a dose-related inhibition of compound 48/80-induced scratching behavior and vasal permeability. Histamine H1-receptor antagonists having antiallergic activity (an inhibition of mast cell degranulation), such as azelastine and non-sedative histamine H1-receptor antagonists such as terfenadine, epinastine and astemizole, also showed a relatively potent effect. On the other hand, the effect of tranilast, antiallergic drug without histamine H1-receptor antagonistic activity, was extremely weak. Diazepam had weak or no depressant effects on compound 48/80-induced scratching behavior. These results suggest that the histamine released from skin mast cells play an important role in the generation of compound 48/80-induced scratching behavior and vasal permeability in mice.

Back to the top.
Poster Number PAsugimoto0283
Keywords: Histamine, Compound 48/80, Scratching, Permeability, H1-antagonists