Abstract

Introduction

Hypothalamic Mechanisms

Ion Channel Modulation by IL-1

Indirect G-protein Modulation

Cytokine Systems

Discussion
Board

Anorexia is a common neurological manifestation of acute and chronic disease, and cytokine immunotherapy using IL-1b. The central administration of IL-1b , at doses that yield estimated pathophysiological concentrations in the cerebrospinal fluid, induces anorexia by reducing meal size and meal duration dose-dependently. Suprapathophysiological doses of IL-1b also decrease meal frequency and induce a generalized behavioral depression. IL-1b-induced anorexia is blocked by the IL-1 receptor antagonist. Various mechanisms are involved in IL-1b-induced anorexia by action in the brain including 1) modulation of hypothalamic neurons via specific changes of ion channel activity; and 2) interactions with neuropeptides, neurotransmitters, hormones, and other cytokines and immunomodulators. These interactions include modulation of ligands, receptors, transducing molecules and intracellular mediators in both, models of central administration of IL-1b and rodent models of disease (e.g., infection, cancer).

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Presentation Number SAplata-salaman0321
Keywords: feeding, brain, cytokine, cancer, infection