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Antioxidant N-acetylcysteine Inhibits Development Of Hypoxic Pulmonary Hypertension In Rats
Herget, J. (Department of Physiology, 2nd Med. School, Charles Uniersity,
Czech Republic)
Bíbová, J. (Department of Physiology, 2nd Med. School, Charles Uniersity,
Czech Republic)
Hampl, V. (Department of Physiology, 2nd Med. School, Charles Uniersity,
Czech Republic)
Contact Person: Jan Herget (Jan.Herget@lfmotol.cuni.cz)
Abstract
Chronic hypoxia results in pulmonary hypertension. Radical injury
to the pulmonary vascular tissue may play a pathogenetic role
(1, 2). We investigated the effect of a preventive administration
of N-acetyl cysteine (NAC, the precursor of reduced glutathione)
in rats exposed to chronic hypoxia. Four groups were studied:
H = exposed to hypoxia (Fi02 = 0.01, 2 wks) with no additional
treatment (n = 7), H+NAC = exposed to hypoxia and treated with
NAC in drinking water (20 g/100 ml, n = 9). N (n = 7) and N+NAC
(n=10) were respective normoxic controls. Group H+NAC had significantly
(p < 0.001) lower pulmonary arterial blood pressure than group
H (21+/-1 torr and 27+/-1 torr respectively). It was, however,
higher than in both groups of air controls (N=15+/-1 and N+NAC=14+/-1
torr). Similar differences were found in the relative weight of
the right ventricle (H=73+/-5, H+NAC=60+/-4, N=46+/-6 and N+NAC=55+/-2
mg/100g of body weight). Cardiac output measured by a Transonic
System (T 106) flowmeter in open chest, ventilated rats and systemic
blood pressure did not differ between the groups.
1. Hoshikawa, Y., S. et al.. Nippon Kyobu shokkan Gakki Yas 33:
1169-1173, 1995. 2. Nakanishi, I., F. et al.. J. Physiol. 489:
869-876, 1995.
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Poster Number PAherget0589
Keywords: hypoxia, lung, hypertension, radical
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