Neuroscience Poster Session

Re: Poster 842

HEINZ Grunze
grunze@psy.med.uni-muenchen.de

On Sun Dec 6, Grover wrote
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>Dr. Grunze: Hope you are enjoying the meeting. Great poster.Could you clarify for me whether based on these results you think that valproate worked only in one patient because acute mania is a multifactorial disorder or because there is difference between patients in the bioavailability of valproate in the brain areas which would be affected by it?
>
Sorry for the late reply. Just to clarify it :4/5 were considered as responders, the non- responder was a ultra-ultra rapid cycling patient. This is, in my opinion, a clearly different state from "normal" bipolar, and seems to be more sensitive to agents regulating intracellular calcium homeostasis. I think that the difference in the presumably underlying pathophysiology explains the non- response in this very special patient.

Thu Dec 10