Stroke/Cerebral Vasospasm

Re: Spasmogens and cerebral vasospasm

John Zhang
jzhang@neurosurgery.umsmed.edu

On Tue Dec 8, Ken McKechnie wrote
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>A very thought provoking paper which highlights some of the shortfalls of invitro studies. Have you considered the possibility of UTP/UDP as a possible agonist being released from the clot or surrounding tissue and acting on the P2 receptors?

Ken,

Thank you for the comment. I believe Lock Macdonald has some answers to your questions too. (his name was not included in the author's list by mistake, and he submitted this paper). I agree with you that UTP/UDP should be released at least from platelets and act on the P2u receptors in smooth muscle cells from cerebral arteries. In our previous studies, we found P2u receptor in rat basilar smooth muscle and the calcium response is more pronounded to UTP/UDP than that of ATP. In isometric tension, dog basilar contracts two times more to UTP than ATP.

Tue Dec 8