Hypertension III: Flow-Induced Vascular Remodeling

Joseph L. Unthank
junthank@iupui.edu

Your results that flow is not altered relative to control animals in the chronic L-NAME group is interesting.  Do you have any data to indicate what happens with acute administration of L-NAME?  

I am also curious how you explain the lack of an increase in flow in the "HI" vessels in the L-NAME group.  If I understand your model correctly, the arterial ligation should decrease pressure in the marginal artery distal to the site of ligation.  If this is true, and L-NAME does not alter flow in the control vessels, then why does flow not increase in the "HI" vessels of the L-NAME group due to the pressure difference?

Sincerely,

Joe