Hypertension III: Flow-Induced Vascular Remodeling

Jo De Mey
j.demey@farmaco.unimaas.nl

In your presentation you describe that SHR display blunted flow-induced mesenteric collateral artery remodeling. These animals are known to display also an impaired flow-induced dilatation. The question now arises whether impaired remodeling is a direct consequence of endothelial-dysfunction or the result of modified local hemodynamics. The contribution of Debbie Ceiler and myself to this symposium demonstrates that pharmacologically-induced endothelial dysfunction (chronic L-NAME) persistently blocks shunting of blood flow through the collateral channels. These findings favor a hemodynamic hypothesis (remodeling would not occur because the flow does not go up).
What were the flows in your SHR experiment?

Kindest regards,
jo