Jeff C. Falcone
jcfalc01@gwise.louisville.edu
Dr. Lee,
The results as displayed would confirm your statement regarding no impairment of
vasodilator response in the SHR. However, we have not completed a complete
dose-response relatioship for either Ach or Adn. The doses we have reported on are the
optimal maximal dose typically used to induce either endothelium-dependent (Ach) or
EC-Indepenent (Adn) dilation. We have also published data that demonstrates that at
this level of vessel (first-order) feed arteriole, the wall structure is not different between
the strains.
Jeff C. Falcone