SERCA-Type of Calcium Pumps and Phospholamban

Re^2: Poster 237

Dr. Chu: These are very interesting results. Thanx. Cheerios.

On Tue Dec 8, Guoxiang Chu wrote
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>On Sun Dec 6, grover wrote
>--------------------------
>>Dr. Chu
>> How do the effects of beta adrenergic stimulation compare in PLB null mice, in mice with PLB introduced and the control mice?

>Dear Dr. Grover:
>1) The PLB null hearts are operating at very high contractile levels and they can only be slightly stimulated by beta-agonists.
>2) The mouse hearts with PLB reintroduced can be stimulated by isoproterenol similarly to wild-type controls.
>3) The maximally-stimulated contractile parameters in all three groups are similar.
>

Tue Dec 8