Molecular Physiology of Sodium-Calcium Exchange

Re^2: Poster 411

Thanx Jonathan: I had not realized that circular transcripts were that common. I am sure it has to be more than the length of an exon alone as there are all sorts of instances where the exon sizes are quite large. I can't think of anything intelligent other than because I don't understand splicing that well.
On Tue Dec 8, Jonathan Lytton wrote
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>On Sun Dec 6, grover wrote
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>>Dr. Li: Fascinating result. I am glad to see your nice presentation and hope you enjoy the meeting. What do you think are the molecular mechanisms which lead to the formation of the circular transcript?
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>Thanks Grover. Interesting question - I forget now if I left this part out, but we think that it may be the unusually large size of exon 2 which allows its 3' end to be arranged in space close to its own 5' end, instead of to the 5' end of the subsequent exon. As a result, circularization is a frequent splicing event. This may also be related to the fact that the exons after exon 2 are subject to alternative splicing. Perhaps this influences kinetics also? Any ideas are welcome!
>-Jonathan

Tue Dec 8