Cytokines, Monoamines and Behavior

Alexander Kusnecov
kusnecov@rci.rutgers.edu

As always a nice body of work. I was wondering whether the effects you observed were specific to challenge during the preweanling stage or whether similar long term effects would occur if post-weaned animals were challenged with a similar regimen of LPS and tested after an identical period of time had elapsed? You may not have tested this, but I think it's important to determine whether the long term effects on behavioral and neuroendocrine responses are dependent on a certain state of immunological maturity and/or neural-immune interactivity specific to the preweanling stage. There is also the possibility that maternal factors vis-a-vis a "sick" pup may influence the long term outcome.